Governments world-wide are walking a tightrope by seeking to limit economic damage with minimum risk to public health and healthcare systems. Research can and should properly inform policymakers and provide both guidance and practical support. The European Commission, national governments and international organisations have the opportunity to take practical steps to guarantee that the resources put together via the Coronavirus Global Response will be used in the most efficient way to achieve its goals as well as to build resilience and improve our readiness to future outbreaks. To this end, five practical steps or “recommendations” to accelerate COVID-19 research have been identified and presented.