Challenge #2: Delivery system for intranasal administration of biological drugs to neonates
INDENEO project wants to push forward a new and innovative delivery system for neonatal population by bringing together an interdisciplinary public – private partnership. This consortium aims to provide an actionable road-map in order to design and test intranasal delivery device for brain therapies. The proposed concept is an innovative electro-mechanical medical device able to gently deposit drops onto the olfactory region of the nasal cavity of neonates. The device will deliver the desired biological drug formulation volume to the specific targeted region of the nasal cavity of neonates, with high reproducibility in a simple, easy-to-use, efficient and safe way. INDENEO device will be designed as a versatile platform able to deliver different molecules or formulations, including cell suspensions. This could further increase the potential impact on therapies to be delivered through this innovative system. The consortium will first work on designing functional prototype and engaging with EMA trough Innovation Task Force. In stage 2, preclinical testing will aim to demonstrate efficient delivery of different biological drug formulations in the brain in vivo in Non-Human Primates.
Name & Nationality
MOREL, Benjamin (Coordinator), EVEON
SMALL AND MEDIUM ENTERPRISE (SME)
LE GRAND, Roger, IDMIT (Infectious Diseases Models for Innovative Therapies)
CILIO, Maria Roberta, Saint-Luc University Hospital, University of Louvain